October 8th
Pelvic Physical Therapy Distance Journal Club
Objective: To
examine the significant “placebo effect” in a randomized, double-blind,
placebo-controlled interstitial cystitis (IC)/bladder pain syndrome (BPS)
trial. Randomized clinical trials are
the reference standard for therapeutic impact assessment however, proving
efficacy of treatments for IC/BPS with rigorous placebo-controlled trials is
difficult due to a significant effect of the placebo intervention.
In past studies, a significant effect has been repeatedly
observed in patients who only received placebo interventions in IC/BPS trials
and the placebo global response assessment overall response ranged from 12% to
20%.
Another study by this same author in 2014 showed 50% of the
placebo patients had an over 50% overall improvement in the global response
assessment.
The significant improvement with only advice and support is
higher than many commonly used medications for the treatment of IC/BPS.
